Proinflammatory cytokines in peritoneal fluid in women with peritoneal adhesions

Abstract

DOI: 10.52705/2788-6190-2023-02-13
УДК 618.34-002:616.381-007.274-005.2:576.3

The objective: to investigate the level of pro-inflammatory cytokines in the peritoneal fluid inwomen of reproductive age with peritoneal adhesions.

Materials and methods. 58 patients verified during laparoscopy were included in the study: ofthem, 45 patients with stages I–II of the adhesion process, 13 – with stages III–IV of the spread ofthe process. The control group consisted of 30 women of reproductive age with intact reproductivefunction without adhesions in the pelvis, who underwent laparoscopic sterilization. The content ofIL-1, i IL-2, IL-6 and tumor necrosis factor alpha in the peritoneal fluid was analyzed.

Results. Studies of the content of pro-inflammatory cytokines IL-1 (192.5±34.8 pg/ml and268.4±48.3 pg/ml), IL-2 (145.9±21.3 pg/ml and 234.8±42.5 pg/ml), IL-6 (118.7±8.4 pg/ml and698.4±22.6 pg/ml) and TNF-α (10.2±4.8 pg/ml and 29.6±2.8 pg/ml) in peritoneal fluid showed thattheir levels were significantly higher (p<0.01) in women with widespread stages of the adhesionprocess and the lowest in CG – 18.2±4.2 pg, respectively/ml, 22.4±4.3 pg/ml and 26.4±4.7 pg/ml.The level of IL-6 – 698.4±22.6 pg/ml in the peritoneal fluid of patients with III–IV stages of the adhesionprocess was significantly higher (p<0.01) than the level of IL-6 – 118.7±8.4 pg/ml in the peritoneal fluidof women with stage I–II spread of adhesions and in the control group – 26.4±4.7 pg/ml.

Сonclusions. With the increase in the prevalence of the adhesion process, there is a significantreliable increase in the content of cytokines in the peritoneal fluid, while the peritoneal fluid playsa significant role in its formation.