Informing of estimation of cytokine status at nonspecific infectious-inflammatory diseases of cervix and vagina

Abstract

DOI: 10.52705/2788-6190-2023-02-7
УДК 618.15-002-022-07

The objective: to estimate informing of estimation of cytokine status at nonspecific infectiousinflammatorydiseases of cervix and vagina.

Materials and methods. 9 type groups are selected: I –conditionally healthy (42 women), II –candidacy (45 women), III – bacterial vaginosis (112 women), IV - a nonspecific vulvovaginitis (107women), V – acute vulvovaginal candidiasis (61 woman), VI - chronic vulvovaginal candidiasis (76women), VII – bacterial vaginosis + candida infection (71 women), VIII - a nonspecific vulvovaginitis+ candida infection (84 women), IX – bacterial vaginosis + nonspecific vulvovaginitis (63 women).To the complex of the conducted researches were included cytological, bacterioscopic,bacteriological and immunological.

Results. Set connection between clinical-and-laboratory by the features of the studied states andbiological properties of stamms of C. albicans, selected from different patients. Together with thecomparative analysis of morphological and cultural descriptions of mycotic cultures the specialinterest was presented by determination of them to pospholipase activity, which is examined asbasic, correlating with other, factor of pathogenicity of C. аlbicans.It is marked, that in those cases, when it is possible it was to foresee participation of C. аlbicansin an infectious process as a monoexciter or fellow member of parasitocenosis, registered themeaningful increase of degree of their virulence for certain. The sizes of cages varied, but morefrequent were below than averages. The coefficient of virulence which correlates with the level ofpospholipase activity hesitated within the limits of 0,3–0,9 and, as a rule, exceeded 0,5.Dependence is marked also on a temperature factor: speed of growth of «virulent» variants at a roomtemperature was considerably slowed, or growth absented in general, that typically for exciters infectiouslyinflammatory diseases. In those cases, when candida discovered for practically healthy women or as«casual», transient components on a background a nonspecific vaginitis or bacterial vaginosis, thecoefficient of virulence of the selected stamms was always below 0,3, a tendency was traced to thejumboizing of cages, here cultures identically well grew and at a room temperature, and at 37 °С. Obviously, that at clarification of diagnosis, for differentiation of the states, C related to infecting. аlbicans,and estimations of their contribution to the infectious process, together with traditional clinical-andlaboratoryby tests, expedient study of the transferred properties of microbal cultures which are selected.

Conclusions. The results of the conducted researches testify to the substantial role of cytokinestatus at the estimation of the state of local factors of defence for patients from infectiouslyinflammatory by the diseases of cervix and vagina. The got results must be taken into account atdevelopment of algorithm of diagnostic and treatment-and-prophylactic measures.