Influence of violations of microbiocenosis of cervix is on the risks of the intraamnial infection

Abstract

DOI: 10.52705/2788-6190-2023-04-7
УДК 618.2/.3+618.39+618.5+579.882+616.9

The objective: study of features of microbiocenosis of sexual ways at the high risk of the intraamnial
infection and development of method of correction of nascent violations.
Materials and methods. It was conducted complex clinical-and-laboratory and functional inspection
150 expectant mothers which were up-diffused on three groups: control are 50 primiparous without
obstetric and somatic pathology; 1 group – 50 primiparous with the high risk of development intraamnial
infection which got the generally accepted treatment-and-prophylactic measures; 2 groups are 50
primiparous with the high risk of development intraamnial infection which with a prophylactic purpose
except for the generally accepted treatment-and-prophylactic measures got system antimycotic in the
generally accepted dosage in the followings terms of pregnancy: 18–20; 28–30 and 36–38 weeks
pregnancies with the purpose of correction of microbiocenosis of sexual ways.
Our choice was done exactly on this preparation, taking into account his high efficiency and wide
spectrum of action, and also low level of side and negative effects and absence of teratogenic effect.
Results. Violations of microbiocenosis of sexual ways which play a substantial role in development
of obstetric and perinatal complications take place at the high risk of the intrauterine infection. The
generally accepted treatment-and-prophylactic measures are not enough effective, that testifies to the
necessity of their improvement. Use offered by us treatment-and-prophylactic method allows to reduce
frequency of placenta disfunction at 2,1 time; delays of development of fetus – 1,9 time; sharpening of
urogenital infection during pregnancy – in 2,0 times; bacterial vaginosis – at 2,1 time; premature births
– at 2,5 time; anomalies of childbirth – at 1,9 time; fetal distress – at 2,3 time; intranatal asphyxia – at
2,1 time; intraamnial infection – at 2,2 time and perinatal losses – in 2 times.
Conclusion. For women high-frequency of violations of microbiocenosis of sexual ways, which
results in development of obstetric and perinatal complications, takes place with the high risk of the
intrauterine infection.
The generally accepted treatment-and-prophylactic measures are not enough effective. Clinical
efficiency of the offered new method of correction of microbiocenosis of sexual ways with the use of
the offered algorithm is confirmed by the results of functional, laboratory, microbiological and virologic
methods of research.