The women of reproductive age have features of the functional state of endometrium with autoimmuny pathology of thyroid

Abstract

DOI: 10.52705/2788-6190-2023-04-10
УДК 618.2-055.23-053.7-083-082:614.2

The objective: to estimate the functional state of endometrium for the women of reproductive age
with autoimmuny pathology of thyroid.
Materials and methods. The comparative estimation of the state of the immune system,
pathological and to the immunohistochemical state of endometrium in 205 women of reproductive
age, which suffer pipe peritoneal by infertility and that appealed for the leadthrough of assisted
reproductive technologies, including 117 patients, with the transmitter of antibodies to the thyroid
(antibodies to thyroperoxidase and antibodies to thyroglobulin) without the parafunction of thyroid
and 88 patients without pathology of thyroid is conducted.
For the estimation of the state of the immune system conducted phenotypical description of
cages of the immune system the method of running cytoflowmetry with application of monoclonal
antibodies.
Results. Found out by us enhanceable frequency of organ-specific (antiovarian) and non organspecific
antibodies for women with the autoimmuny diseases of thyroid as compared to the group
of women without pathology of thyroid sustains a theory of generalized of autoimmuny disfunction
for these women, the marker of which are antithyroid antibodies. In addition, in endometrium of
women with the autoimmuny diseases of thyroid in the phase of proliferation inflammatory similar
changes are marked with formation of the dissipated lumphocytic infiltration of stroma by the
increase of number of cages, that express markers of plasmatic cages of CD138, natural killers of
CD56 and macrophages of CD68; strengthening of processes of apoptosis of cages (Apaf-1) is in
an epithelium and stroma of endometrium.
Conclusion. In a period the «window of implantation» in endometrium for women with the
autoimmuny diseases of thyroid found out 3th multiple decline of expression of key marker
of receptivity of endometrium – LIF, that can is reason of failures of implantation during the
leadthrough of the program of assisted reproductive technologies. The got results must be taken
into account at development of algorithm of diagnostic and treatment-and-prophylactic measures.