Pressing questions of pathogeny of combination of genital endometriosis and hypothyroidism

Abstract

DOI: 10.52705/2788-6190-2024-03.2-07
УДК 618.17-007.415:616.441-008.64:612.018.2

The objective: to set the features of pathogeny of genital endometriosis of hypothyroidism.
Materials and methods. By us it was inspected 110 patients of reproductive age from 20 to 41 year with external genital endometriosis. All women parted on two groups. In the first group 50 patients entered with external genital endometriosis without pathology of thyroid, in a friend – 60 women with external genital endometriosis and concomitant hypothyroidism. The clinical groups of patients are formed thus: the first group was made 10 (20%) patients which treated oneself concerning infertility and during an inspection there were found out the hearths of external genital endometriosis on the peritoneum of small pelvis; that 15 (30%) appealed to the gynaecologist with complaints about dysmenorrhea, dyspaurenia, pains in the area of pelvis and at a complex inspection was found out external genital endometriosis; 25 (50%) patients which acted on the planned operative treatment concerning the endometrioid ovarian cysts. To the complex of the conducted researches were included clinical, echographic, immunological, endocrinology and statistical methods.
Results. Secretion of thyrotropic hormone for women with external genital endometriosis and with subclinical and by a manifest hypothyroidism was considerably (р<0,01) more high as compared to such in the group of patients with external genital endometriosis without pathology of thyroid, and also higher than normative indexes. At obvious or manifest hypothyroidism together with the increase of level of thyrotropic hormone the reduced level of fT4 is determined (free thyroxine). The hyperproduction of thyrotropic hormone for patients with external genital endometriosis at hypofunction of thyroid are instrumental in diminishing of level of follicle-stimulating hormone to the increase of products of prolactin, that results in the decline of estrogen-producing function of ovaries.
Conclusions. The results of the conducted researches testify to the substantial role of endocrinology status in pathogeny of external genital endometriosis on a background a hypothyroidism. The got results must be taken into account at development of tactic of conduct of these patients.