Clinical­and­anamnestic features of hyperproliferative processes of mammary glands

Abstract

DOI: 10.52705/2788-6190-2024-03.2-10
УДК 618.1-06:618.19

The objective: Study of features of reproductive anamnesis and clinical symptoms fibrocystic disease.
Materials and methods. An inspection was conducted 100 patients with a diagnosis fibrocystic disease. The criteria of including for it were: age 20-49 years; presence of clinical, ultrasonic, morphological signs fibrocystic disease; body mass index not more than 29,9 kg/m2 . The criteria of exception from research served as: suspecting or confirmation of malignant process is of mammary gland, pregnancy, puerperium, lactation, use during the last 6 months hormonal facilities. The group of comparison was made by 50 women. The criteria of including for it were: age 20–49 years, absence of clinical symptoms of disease of mammary glands, absence of hyperplastic processes in other organs of the reproductive system, regular menstrual cycle. An inspection included, together with the generally accepted methods, physical and ultrasonic research of mammary glands, Doppler with coloured Doppler mapping of blood stream in the arteries of parenchima, hormonal research, intraoperative biopsy and morphological methods. With the purpose of quantitative estimation of intensity of mastalgia used by visual analogue scale, information of palpation– ball estimation.
Results. Results testify to the nosotropic value clinical-and-anamnestic factors in development fibrocystic disease, which is determined by postnatal character morpho-functional to development of mammary glands, which is synchronized with the periods of becoming of ovulatory and hormonal functions of ovaries by realization of reproductive function of woman. Rotined dependence of intensity of pain syndrome on age of patients, indexes of hormonal function of ovaries, development of parenchima and degree of it cyclic transformation. Thus the conduct of multiple regression analysis allowed to set that basic factors which influence on intensity of mastalgia is a thickness of parenchima (F = 58,17) and level in blood of estradiol (F = 154,92) in the second phase of menstrual cycle.
Conclusions. The got results it must draw on at development of complex of diagnostic and treatment-and-prophylactic measures.