Influence of hyperandrogenism in anamnesis on endocrinological status and content of placental proteins in a fetoplacental complex

Abstract

DOI: 10.52705/2788-6190-2024-04.1-02
УДК 618.36:612.616.31

The objective: study of the state of endocrinology status and content of placenta proteins of fetoplacental complex for women from hyperandrogenism in anamnesis.
Materials and methods. For the decision of the put purpose studied the features of premorbid background, motion of pregnancy and functional state of fetoplacental complex (endocrinological status and content of placental proteins) in 50 women from hyperandrogenism in anamnesis – I group. For comparison used analogical information in 50 obstetric and somatically healthy
women, vaginal delivery is a control group.
To the complex of methods of researches were included clinical, echographic, instrumental and laboratory methods. 
Results. Complex determination of hormones and placental proteins, which characterize the state of fetoplacental complex from one side, and from other – functioning of bark of adrenal glands, allowed to make the integral picture of features of endocrine mutual relations in the dynamics of pregnancy for women from hyperandrogenism and to find out the most exact criteria which allow to estimate the intrauterine state of fetus and to forecast the result of pregnancy.
Conclusions. Placenta disfunction for women from hyperandrogenism develops from 16 week pregnancies on a background expressed dyshormonal and dysmetabolic violations: in 16–20 week it is a characteristic decline of content of placenta lactogen, estriol and cortisol on a background the simultaneous increase of concentration of placental proteins – placental α1 microglibulin;
α2 fertility microglibulin and trophoblastic β-glycoprotein. Additionally to it, from 24 week the level of testosterone diminishes for certain, and after 32 week – 17-hydroxyprogesterone and dehydroepiandrosterone-sulfat.
The timely estimation of endocrinological status and content of placental proteins allows adequately to estimate the level of perinatal risk and conduct the correction of treatment-andprophylactic measures.