Frequency of exposure of carriage of exciters perinatally significant infections for pregnant and estimation of their significance at the intrauterine infection

Abstract

DOI: 10.52705/2788-6190-2025-01.1-03
УДК 618.3/.7-06-036.8:618.33-022.7-053.1-078

Research purpose. Study of frequency of carriage of exciters perinatally significant infections for pregnant and estimation of their significance at the intrauterine infection.
Materials and methods. Study of frequency of exposure of carriage of exciters perinatally significant infections in 1000 pregnant women of inspected on the carriage of the most significant infections including from TORCH- complex, parallell with prenatal screening of I of trimester (11-13 weeks 6 days) on congenital and hereditary diseases. The statistical analysis of the got data on frequency of exposure is executed after the generally accepted methods.
Results. At the screening inspection of pregnant on the carriage of exciters perinatally significant infections, to the TORCH-complex and ultrasonic screening of the state of fetus found out that the most of women it is pregnant from IgG by antibodies to Herpes of simplex-1,2 (to 94%), and from IgG by antibodies to Cytomegalovirus (to 72,5%), thus the signs of the intrauterine infection during pregnancy considerably more frequent develop at presence of IgG of antibodies to Herpes of simplex-1,2, (more than half of pregnant) and are 52,7%. At presence of IgG of antibodies to Cytomegalovirus this percent was at the level of 17,4%. Without regard to less of pregnant from IgG by antibodies to Chlamydia trachomatis (24%), the signs of the intrauterine infection found out in 40,7% cases. The carriage of Candida albicans and Staphylococcus aureus is also related to the intrauterine infection and arrives at 29,6% in first case and 23,4% in the second. Pays attention on itself variety of clinical displays of the intrauterine infection, but most significant is a polyhydramnios (to 81,8%) and fetal growth retardation (to 67,3%). The polymerase chain reaction of verification of exciters is conducted in 37,7% pregnant from all inspected by the method enzyme-linked immunosorbent assay in the presence of antibodies to the exciters of TORCH-infection, positivity, on the average, 94,2%. To the special group of risk in relation to development of intrauterine fetal infection and new-born the pregnant belong with the presence of IgG of antibodies to Herpes of simplex 1,2, IgG of antibodies of Chlamydia trachomatis and with a carriage during pregnancy of Staphylococcus aureus, Candida albicans, and the new-born have the greatest risk of intrauterine infection from mothers with the mixt- carriage of exciters of perinatal infections. The less risk of intrauterine infections must put at presence of in the mothers of IgG of antibodies to Cytomegalovirus.
Conclusion. The got job performances allow to improve prognostication of hyphen of intrauterine infections and complicated by the infectious process of motion of early neonatal period in new-born from mothers with the carriage of exciters perinatally significant infections, especially during work with «practically healthy» pregnant in which in blood found out the method of enzyme-linked immunosorbent assa IgG of antibody to the exciters of TORCH-infection, that enables to optimize the conduct of pregnancy and births, reduce the medical loading on pregnant, to eliminate a stationary help at the signs (from data of ultrasound examination) of the intrauterine infection, but without the risk (from data of prognostic algorithm) of development of intrauterine infection, in good time to render the specialized help to new-born with the high risk of infectious complications in an early neonatal period and thus to reduce the level of disability and death rate of children.