Clinical­anamnestic aspects of patients with endometrial polips in postmenopause

Abstract

DOI: 10.52705/2788-6190-2025-01.2-06
УДК 618.173:618.14-006.5-071.1

The objective: to learn clinical-and-anamnestic aspects for patients with endometrial polips inpostmenopause.

Materials and methods. Research objects were become by 120 patients in postmenopause. Fromthem 90 patients are with endometrial, including without malifnancy made I recurrent polips – basicgroup and II – control group 30 women without endometrial polips, but which are in a position ofresearch of endometrium in postmenopause (serozometer, intrauterine synechias on a backgroundage-old atrophy, artifacts at ultrasonic research which it appears during the conduct of hysteroscopy).In the process of work the modern methods of research are used: clinical (general andgynaecological examination), laboratory (biochemical analysis, cytological research, morphological,immunohistochemical research of scraping of the of mucous membrane of the uterine body,research of backterioscopy, polymerase chain reaction and microbiological research of mucousmembrabe of cervical canal and cavity of uterus.

Results. At the analysis of structure of diseases of organs of the reproductive system for thepatients of basic group found out for certain higher frequency of inflammatory diseases, operativeinterferences, especially intrauterine manipulations as compared to the group of control.It is discovered that more frequent all there were inflammatory diseases of genital organs inanamnesis: vulvitis, salpingo-oophoritis, endometritis, which in two times more frequent wasobserved in the group of inspected with endometrial polips, what in the group of control and were54 (60,0%) and 8 (26,7%) (p<0,01), respectively.It was rotined that risk of appearance of endometrial polips for women with inflammatory diseaseof genital organs for certain higher (RR=2,25; OR=4,13; 95% CI 1,21–4,17), here a sensitivenesswas 87%, and specificity – 38%.The conducted research rotined that approximately in 10% inspected women, both with the polips ofendometrium and healthy, in postmenopause took place bacterial vaginosis, which appeared absenceof expressed leukocytosis (leucocytes to 20 in sight), by the presence of the extensive mixed flora bythe exposure of «key» cells in the vaginal painting. However unlike the group of control in 30 patientswith endometrial polips the expressed inflammatory process of vagina took place also.

Conclusions. Complex analysis of clinical-and-anamnestic information found out the rowof features which are a favourable background for development of endometrial polips inpostmenopause. For patients with endometrial polips, by comparison to a control group, morefrequent there were somatopathies, inflammatory diseases of genital organs, violation of thereproductive system, endometrial manipulations were conducted.Violation of microbiocenosis and local immunity of sexual ways results in development of chronicendometritis, that at presence of unfavorable factors on a background atrophy of endometrium inpostmenopause serves as reason of decline of blood stream with development of hypoxia formingof polips of endometrium.