Influence of hyperandrogenism in anamnesis on changing to hemostasis during pregnancy

Abstract

DOI: 10.52705/2788-6190-2025-02.1-03
УДК 618.3-06:616.154:577.175.5]-071.1

The objective: study of the state to hemostasis for women from hyperandrogenism in anamnesis.
Materials and methods. The analysis of the system of regulation of the aggregate state of blood is conducted in 88 pregnant in 30–34 weeks of gestation with placenta dysfunction, conditioned hyperandrogenism and estimation of efficiency of its correction on the basis of laboratory and morphological criteria. The pregnant are inspected with first found out the during pregnancy increased level of androgens, the source of which was not set, and to the moment researches which had the compensated and subcompensated forms of placenta dysfunction. The indicated groups differentiated on principle of its treatment. For the prophylaxis of hemoreological violations, in the complex of treatment to the patients of I of group (n = 48) sulodexide was included for 600 units (2,0) of intramuscularly 1 one time per a day – 10 days with the subsequent passing to the peroral reception for 250 units twice in days, and the II groups (n = 40) are infusion 5 ml of trental N5 through a day with the subsequent passing to the peroral reception of preparation during 30 days. Groups were identical on age, to social and anamnestic information. To the complex of methods of researches were included clinical, echographic, instrumental and laboratory methods.
Results. At the analysis of indexes of the system of hemostasis to the end of II - to beginning of the III trimester of pregnancy the state of thrombophilia was set for patients from hyperandrogenism (without meaningful differences between the groups of pregnant from hyperandrogenism), that is characterized by activating platelet-vascular and coagulative links to hemostasis. Therefore conduct of therapy of sulodexide, directed on normalization of the aggregate state of blood for pregnant with placenta dysfunction on a background hyperandrogenism nosotropic grounded and effectively.
Conclusions. The results of the conducted researches testify that changes system to hemostasis have a substantial value in pathogenesis of obstetric complications for women from hyperandrogenism in anamnesis. Including to the complex of treatment-and-prophylactic measures according to a correction allows to normalize the state system to hemostasis and to improve the obstetric results of motion of pregnancy.