Influence of different microbiocenosiss of mother is on composition of intestinal microflora of child

Abstract

DOI: 10.52705/2788-6190-2025-02.1-19
УДК 616.34-008.87-053.3-06:618.63-022.7

The objective: to estimate influence of different microbiocenosiss of mother on composition of intestinal microflora of child.
Materials and methods. All is inspected 250 children in age from 1 month to 3 years and 100 mothers. General criteria of plugging are in research of children: gestational term at birth 38-41 week, mass of body 3000–4000 g, absence in anamnesis of antibacterial therapy and acute intestine of infections 2 months prior to the conduct of research. After registration of consent to medical interference and in accordance with the criteria of including and exception the type groups of children were formed. To the complex of the conducted researches were included clinical, microbiological, virologic, biochemical and statistical.
Results. Among studied the found out the stamms of lactobacilli is with a potentially пробіотичним effect: 5 stamms of lactobacilli which own high antagonism activity in relation to S. aureus and 4 stamms of high antagonism activity on the relation of hemolyzing E.coli. Most interest presents the stamm of Lfrom this point of L.fermentum № 30/4, that owns high antagonism activity in relation to both microorganisms. High-frequency of resistance of intestinal lactobacilli is set to the more frequent all in-use antibiotics and chemotherapy. All lactobacilli were multidrug-resistant and had from 8 to 15 markers of resistance. All stamms of intestinal lactobacilli were resistant to furazolidone, ciprofloxacin, co-trimoxazole, ceftriaxone, nitroxolinum, metronidazole; 75% stamms showed resistance to amikacin and to the ampicillin; 65% stamms – to amoxiclav and cefotaxime; 70% stamms were sensible to penicillin and linezolidum, 60–65% – to erythromycin and lincomycin.
Conclusions. Found out the row of features of specific composition, antagonism activity and antibiotic resistance of intestinal lactobacilli for the children of infancy. Findings it follows to take into account at setting to the children of antibacterial preparations concerning intercurrent infections and choice of probiotics for the correction of composition of intestinal microbiocenosis.