Mikrobiologichni of feature of pathogenesis of hyperplastic processes of uterus

Abstract

DOI: 10.52705/2788-6190-2024-03.2-09
УДК 618.14-002718-007.61-092-02:616.9

The objective: establishment of role infectious to the pathogen in development of hyperplastic processes of uterus.
Materials and methods. 250 women which were up-diffused on five groups were inspected. Plugging criteria are in research: presence of the combined hyperplastic processes of uterus – two and more for a disease (hyperplasia of endometrium, uterine fibroids and adenomiosis), verified morphologically, of fertile age (25–45 years). On the basis of clinical motion of disease, information of genital status and pathomorphological conclusion the followings groups were formed: I a group was made by 50 women with the hyperplastic process of endometrium and uterine fibroids, II group – 50 women with the hyperplastic process of endometrium and adenomiosis; III group – 50 patients with combination of three diseases – adenomiosis, uterine fibroids and hyperplasia of endometrium. Foundation for plugging in the group of comparison was a presence exceptionally of hyperplasia of endometrium (without combination with uterine fibroids and adenomiosis, IV is a group) (information retrospective inspection, n=50). The control V group was made by 50 women from a contingent gynaecological of healthy (for comparison of immunological indexes). In the complex of the conducted researches were used clinical, microbiological, echographic, endocrinology, morphological and statistical methods.
Results. It is set pathomorphological researches of operating biopsy (endometrium, uterine fibroids and adenomiosis cavity), that for patients with combination of hyperplasia of endometrium with a uterine fibroids and adenomiosis is the signs of chronic inflammatory process in tissue of uterus. Infecting of tissue of endometrium and myometrium de bene esse by pathogenic microorganisms (21,7% women are with the hyperplastic processes of uterus); staggered by them not only mucus membrane but also myocytes (in 26,9% – with uterine fibroids, 16,1% – hyperplasia of endometrium, 40% – from adenomiosis). High middle title of Mycoplasma of hominis. Correlation of hyperplastic diseases of uterus is with the stamms of mutants of Mycoplasma of hominis
(r=+0,36; p=0,012).
Conclusion. The got results allow to examine infectious pathogens as cofactors of hyperplastic processes uteruses, nosotropic related to the representatives of flora of lower parts of the genital tract and such which take participating in realization of inflammatory process.