Women have features of metabolic syndrome and thyroid pathology after natural and surgical menopause

Abstract

DOI: 10.52705/2788-6190-2025-02.1-12
УДК 616.173-089.168.1-06.616.441-002-039

The objective: to learn the features of metabolic syndrome and thyroid pathology for women after natural and surgical menopause.
Materials and methods. For the study of features of metabolic syndrome and pathology of thyroid gland in perimenopause one-time research of population is conducted 150 women in age 45–55 (Me [25; 75] = 49 [47,0; 52,0] years). Group 1 – «преmenopause», n = 50; group 2 is «natural menopause», n = 50; for the study of features of pathology of thyroid gland after surgical menopause the third group of women (n = 50), chosen by a casual method from a number operated in the volume of hysterectomy in combination with bilateral oophorectomy was formed. To the complex of the conducted researches clinical, laboratory instrumental and statistical methods were included.
Results. The value of body mass index and his changes in development of metabolic syndrome was studied in euthyroid women after surgical menopause during prospective randomized clinical research during 5 years. Obesities to the operation had 40,0% patients. In 5 years after surgical menopause frequency of obesity and was 48,0%. The dynamics of body mass index made, on the
average, 1,1 ± 0,3 kg/m2. The broken tolerance to glucose and saccharine diabetes developed in 28,0%, metabolic syndrome of menopause – in 38,0% women. Frequency of hypertension to the end of supervision was 58,0%.
Conclusions. Pathology of thyroid gland for women 45–55 years can be instrumental in the risk of development for it of metabolic syndrome during the nearest 5 years, especially at presence of making progress obesity in combination with a hyperglycaemia, surgical menopause and burdened heredity on obesity, hypertension and saccharine diabetes. For the prophylaxis of development of metabolic syndrome an enough decline of body mass index is on 4,5% or absence of increase of mass of body after menopause.