The women of reproductive age have ways of decline of the repeated pathology to endometrium

Abstract

DOI: 10.52705/2788-6190-2023-03-9
УДК 618.141-006.5-036.65-02:618.17/.5-08-039.71

The objective. Optimization of tactic of conduct of women of reproductive age is after the delete of polypes to endometrium on the basis of study of antioxidant status of organism and uterine blood stream.
Materials and methods. 165 women of reproductive age took part in research. From them - 150 with polyps to endometrium and 15 practically healthy women of reproductive age with regular ovulatory by a menstrual cycle, which did not have gynaecological diseases in anamnesis, and made a control group.
Results. Ultrasonic research of organs of small pelvis in combination with coloured Doppler mapping and enables the curves of speeds of blood stream non-invasive to estimate the change of indexes of blood stream to myо-endometrium in case of occurring of polyps to endometrium. For patients with polyps to endometrium as compared to the women of control group in the follicle phase of menstrual cycle for certain the low values of index of resistance were determined only in radial and basale arteries (in radial arteries - 0,58 ± 0,01 and 0,66 ± 0,01, respectively; p <0,01; in basale arteries - 0,50 ± 0,01 and 0,57 ± 0,01, respectively; p <0,01). Research results rotined that fibrosis of stroma mainly had met for patients which have glandular-fibrotic polyps to endometrium. Leykocyte-histiocutic infiltration was characteristic to the glandular polyps, and lymphocytic infiltration – glandular-fibrotic to the polyps to endometrium. Both glandular and glandular-fibrotic polyps were characterized by the thick-walled vessels. Vessels with the sclerosis of walls met only in glandular-fibrotic polyps in 17,4% cases. At polyps to endometrium of uterus to and in the first days intensification of processes of free-radical oxidization and peroxide oxidization of lipid took place after operative interference, to what the decline of indexes of antiradical activity testifies an increase of level of malonic dialdehyde (one of products of peroxide degradation of lipids), that sure, is confirmation of activating of processes of free-radical oxidization on the whole, and peroxide oxidization of lipids in particular.
Conclusion. For prognostication of possible risk of relapse of polyps of endometrium after their operative delete it is suggested to conduct the Doppler monitoring with the use of method of coloured Doppler mapping in the basale and radial arteries of uterus in a postoperative period in a dynamics. A positive therapeutic effect is got after the algorithm which includes the complex use of antioxidant preparations (thioctic and ascorbic acid, alpha tocopherol and indole-3-carbinol) in combination with the non-invasive satiation of tissue by electrons developed by us, can allow to revise some traditional going near treatment of hyperplastic processes of reproductive organs for women, that, no doubt, requires the modern methodological and methodical approaches scientifically grounded.