Endocrinological features of the functional state of ovaries after hysterectomy

Abstract

DOI: 10.52705/2788-6190-2024-04.1-08
УДК 618.14-089.87-02:618.11-036

The objective: to estimate the features of dishormonal violations for women after hysterectomy.
Materials and methods. The complex is conducted clinical-and-laboratory inspection 200 patients, which carried surgical treatment uterine fibroids from which 100 women were inspected prospectively (group A) and 100 – retrospectively (group B). Depending on the volume of operative interference, patient parted on two groups: the first group (basic group) was made by 100 patients after a myomectomy, 100 patients which carried subtotal hysterectomy entered in the second group (group of comparison). In the group of prospective supervision selected two sub-groups: I A a sub-group was made 50 patients which carried a myomectomy and II A sub-group – 50 women after hysterectomy. In the group of retrospective supervision a to 1 sub-group entered 50 patients after a myomectomy and in a II B sub-group – 50 patients after hysterectomy.
In the group of prospective supervision conducted research to the operation, in an early postoperative period and through 3, 6 and 12 months after an operation. In the group of retrospective supervision researches were conducted in 2–10 years after operative treatment. At the study of hormonal type content of prolactin was determined, gonadotropic hormones, estradiol, progesterone, thyroid hormones, androgens in plasma of peripheral blood. Determinations of concentration of hormones conducted after the generally accepted methods.
Results. At the estimation of level of estradiol after both types of surgical treatment of uterine fibroids the reliable decline of level of estradiol was fixed in blood, in a greater degree expressed after hysterectomy. At a subsequent supervision, the gradual increase of maintenance is marked in blood of this hormone, thus in a year after a myomectomy there was complete renewal of level
of estradiol, and after hysterectomy his level continued to remain for certain mionectic both by comparison to the preoperated level and at intergroup comparison. At a supervision in remote terms after hysterectomy, the reliable decline of level of estradiol was saved both at intergroup comparison and as compared to the preoperated level.
After a myomectomy, in 2–4 years, the level of estradiol did not have reliable differences with preoperated, and through 5 and more than years after a organ-preserving operation it took place him reliable decline. At the intergroup analysis of content of progesterone in the sub-groups of retrospective supervision, marked for certain higher level of this hormone in a 1 sub-group in 2-4
years (р=0,011) and through 5 and more than years after an operation (р=0,009), as compared to a IIB sub-group.
Conclusions. Got information endocrinological researches testify that women after hysterectomy make the group of high risk in relation to possible development of ovarian neoplasms in different terms after surgical treatment. Findings need to be taken into account at development of algorithm of diagnostic and prognostic measures for women after hysterectomy.