Features of intercommunication are between the methods of assisted reproductive technologies and perinatal consequences of delivery

Abstract

DOI: 10.52705/2788-6190-2025-01.1-07
УДК 618.3/7-06:618.177-08.888.11-039

Research purpose. To estimate the perinatal consequences of delivery for women with the different methods of assisted reproductive technologies.
Materials and methods. For the decision of the put purpose the closed prospective comparative research to which entered 365 pregnant is conducted, after assisted reproductive technologies (in vitro fertilization / intracytoplasmic sperm injection / cryopreserved embryos: from them 107 patients are with multiple pregnancy (group of 1В). The group of comparison was made by 394 women with spontaneous pregnancy, from them 92 – with multiple pregnancy (group of 2В). The criteria of including of patients in research were the uterogestation which came involuntary or after assisted reproductive technologies confirmed by an ultrasonic method, presence in the cavity of uterus in a 1 trimester of pregnancy not more than 2 embryos. The criteria of exception were a presence of heavy extragenital pathology, acute infectious diseases, intensifying of gynaecological diseases during pregnancy, acute infectious and inflammatory diseases during pregnancy. To the complex of the conducted researches were included clinical instrumental, laboratory and statistical.
Results. The analysis of motion and results of pregnancy did not find out statistically reliable differences at the different method of achievement of pregnancy (induced or involuntary). The conducted analysis rotined that frequency of the threatening breaking of pregnancy is marked in a control group in 16,4%, at the induced pregnancy – in 17,9% (p>0,05). Gestational diabetes met more frequent at the induced pregnancy, however much differences were reliable (2,9% and 1,3%, ð>0.05). Also it was not marked statistically meaningful differences in frequency of exposure of anaemia of pregnant, activating of chronic viral infections. Among complications of pregnancy only arterial hypertension which is induced by pregnancy, a few more frequent met in a control group (3,7 and 2,9%, p>0,05). Frequency of placenta dysfunction on groups did not differentiate also (15% and 15,1%). The middle term of delivery made 38,1±1,3 weeks at the induced singleton pregnancy and 38,3±2,3 weeks at involuntary pregnancy (р>0,05). All the children gave birth in the satisfactory state, frequency of estimation for Apgar less than 8 points (6-7 points) on groups did not differentiate (1,3% and 1,5 %). To put all written home in the satisfactory state on 5-8 days.
Conclusion. At the exception of risk factors (multiple pregnancy, age more senior 35 years, body mass index more than 25, neuroendocrine pathology, immune violations, arterial hypertension, kidney disease, uterine fibroids, infertility (except for pipe peritoneal and masculine), unfavorable motion / investigation of previous pregnancies (usual miscarriage) complication of assisted reproductive technologies (syndrome of overstimulation of ovaries) a statistical analysis did not find out reliable differences in motion and results of pregnancy at the different method of its achievement. The got results must be taken into account at development of algorithm of diagnostic and treatment-and-prophylactic measures for women after assisted reproductive technologies.