Women have metabolic violations after hysterectomy

Abstract

DOI: 10.52705/2788-6190-2025-01.1-08
УДК 616-008.9-055.2-06:618.14-089.85

The objective: to learn the features of metabolic violations after hysterectomy.
Materials and methods. 126 women which concerning adenomyosis or uterine fibroids in combination with adenomyosis was executed hysterectomy without appendages are inspected. Depending on duration of postoperative period and character of therapy which is conducted, the IV groups were formed. The first (I) group included 26 women in 1 year after hysterectomy, second (II) group – 39 patients through 3, the third (III) group is 39 women in 5 years after an operation. A control group was made by 21 patients in age 44, 5 ± 1,6, that are on a clinical supervision concerning a uterine fibroids hysteromyoma or myoma in combination with adenomyosis. In a fourth (IV) group 22 women entered with overweight (body mass index > 30). To the complex of the conducted researches clinical, laboratory instrumental and statistical methods were included. Results. Research of carbohydrate exchange rotined on a background the conduct of glucose tolerance test, that level of insulin resistance index test in all three sub-groups exceed normal values, making respectively: 32,5 ± 3,2 mkU/ml, 32,8 ± 3,7 mkU/ml, 33,8 ± 3,4 mkU/ml (р > 0,05). The index of С-Peptide, remaining stably normal in the first two sub-groups, is increased at 2,5 time (р < 0,01) to the fifth year after an operation, both as compared to a norm and as compared to control. Researches of lipid exchange did not find out considerable changes in the levels of general cholesterol, of high-density lipoproteins and triglycerides in all three sub-groups inspected. However it should be noted that, beginning from the third year after an operation, marked meaningful increase of general cholesterol as compared to a control group, yet it is more expressed to 5 year after hysterectomy. Level of general cholesterol in IIa and Sha sub-groups made 210,3 ± 12,3 mg/dl and 219,3±20,8 mg/dl respectively as compared to 188,8 ± 16,5 mg/dl of control (р < 0,05). In all sub-groups, especially in IIIa, the increase of aterogenic lipid fraction is marked –of low-density lipoproteins both as compared to control and as compared to a norm (р < 0,05).
Conclusions. Hysterectomy without appendages is the factor of risk of forming (progress) of metabolic violations for women reproductive and perimenopausal period. Character and degree of expressed of metabolic violations depends on duration of postoperative period. Findings must be taken into account at development of algorithm of diagnostic and treatment-and-prophylactic measures.