Women have clinical motion of benigh pathology of mammary glands with different violations of thyroid status

Abstract

DOI: 10.52705/2788-6190-2025-01.1-21
УДК 618719-006.03-055.2-06:616.441-002

Research purpose. To learn the features of clinical motion of benigh pathology of mammary glands for women with different violations of thyroid status.
Materials and methods. For the decision of the put purpose 346 women were inspected more senior 40 years. After a careful clinical and laboratory inspection there was the selected group from 337 women in age from 40 to 60 years, which were up-diffused on 5 groups depending on functional status of thyroid gland and state of mammary glands. A basic group was made by 254 women with the diseases of thyroid gland, which parted on 3 groups taking into account the functional state of thyroid gland. In each of basic groups it was selected for 2 sub-groups depending on the presence of mastopathy: I a group is 105 women in a state of euthyroidism (I A a group is 69 women from mastopathy and I B a group is 36 women without pathology of mammary glands); The II group is 92 women with a hypothyroidism (II A a group is 69 women from mastopathy and II B a group is 23 patients without fibrocystic mastopathy); III group is 57 patients with hyperthyroidism (III A a group is 37 women, sufferings fibrocystic mastopathy and III B a group is 20 women without mastopathy). The group of comparison was made by 32 women from mastopathy without the diseases of thyroid gland (IV group). A control group consisted of a 51 healthy woman without pathology of thyroid gland and mammary glands (V group).
Results. The nodes form of mastopathy was characterized by changes, described above, but that have local character as sporadic or a few nodes. Palpation on a background the glands of soft-elastic consistency separate compressions without clear limits, not soldered with a skin, were determined, that increased the day before and diminish upon termination of menstruations. On mammography a picture was determined fibrocystic mastopathy, however more expressed changes were and carried local character. At ultrasound examination of mammary glands a picture was identical. The areas of expressed fibrosis were determined on a background reduced echoicity. In the group of comparison (with isolated mastopathy) prevailed cystic (13 women - 44,83%) and mixed mastopathy (9 women - 31,03%). A stethalgia was disturbed by 16 women (50,0%). 56,25% patients marked premenstrual character of pain and in 43,75% patients mastalgia was constant. A galactorrhea was observed in 14 women with isolated mastopathy (43,75%). Palpation plural cystic formations of elastic consistency, glands well enough marked off from near-by tissue, were determined. At the mixed form ponderous areas palpated also. On mammography the plural clearing up more frequent of regular shape was determined with clear contours diameter from 0,28 to 4 sm on a background glandular tissue and diffuse duectasia, which formed a large-lobed picture. At presence of the mixed form of mastopathy a X-ray picture was complemented by the homogeneous areas of fibrotic ponderous.
Conclusion. Authenticity of development of dishormonal hyperplasia of mammary glands grew at the increase of degree of severity of thyroid disfunction (hypo-, to hyperthyroidism) increase of remoteness of disease of thyroid gland (hypo- and euthyroidism). More than all felt like the dishormonal changes of mammary glands of woman in a state of hypothyroidism. Frequency of fibroadenomatosis patients from hyper- and euthyroid pathology of thyroid gland of were identical. By the prevailing forms of mastopathy for women from hypo- and euthyroid pathology of thyroid gland were fibrotic and mixed mastopathy. At a thyrotoxicosis prevailed mixed and glandular mastopathy. For patients without pathology of thyroid gland (in the group of comparison) there was characteristic mastopathy with predominance of cystic component and the mixed variant fibrocystic mastopathy.