Role of genetic violations in development of pelvic organ prolapse for women

Abstract

DOI: 10.52705/2788-6190-2025-02.1-08
УДК 618.1-007.44-036:575.113

The objective: to set the role of genetic violations in development of pelvic organ prolapse.
Materials and methods. For the decision of the put purpose in research were included 200 patients, passing inspection and treatment concerning pelvic organ prolapse organs and/or other gynaecological pathology, and also patients without pelvic organ prolapse. All patients parted on two clinical groups: was a basic group made by 100 patients with pelvic organ prolapse, second group – 100 patients is a control group. All patients of every clinical group in same queue parted on 3 sub-groups depending on the age-related period: reproductive (25–45 years), perimenopausal – from 46 years to menopause and in two years after it (46–55 years), postmenopausal– from a moment the offensive of menopause to 65 years. Except for the generally accepted clinical and additional methods of research to all patients it was conducted genotyping on genes to the candidates: for the patients of basic and control group frequencies of met of polymorphic alleles of genes of FBLN5 and LOXL1 were compared, and also area of chromosome 9q21.
Results. Within the framework of our research we analysed connection of polymorphic variants of genes of FBLN5 and LOXL1 not only with pelvic organ prolapse but also with a stress incontinence of urine and with chronic venous insufficiency. A present for us selection parted on two sub-groups: 1) sub-group with a stress incontinence of urine and 2) sub-group with chronic venous insufficiency. A statistical analysis was further executed 11 studied sites of genes of FBLN5 and 2 sites of gene of LOXL1 with an amendment on age, body mass index (and presence of cystocele for a selection with a stress incontinence of urine). We got next results. Among women with a stress incontinence of urine alleles of rs2498841–Т and rs2430369-С gene of FBLN5 were exposed, which more frequent met for the patients of basic group, what in a control group.
Conclusions. It is thus rotined in the conducted research, that genetic variability of both key genes, supervisory the processes of synthesis and degradation of elastic tissue, FBLN5 and LOXL1, influences on the risk of development of pelvic organ prolapse. This effect was most strongly expressed for patients, having two and more than births through natural birth canal in anamnesis. Findings allow to suppose that a parity is important provoking pelvic organ prolapse factor, and the genes of FBLN5 and LOXL1 play an important role in renewal weak as a result of births through the natural birth canal of ligamentary vehicle. One of the most interesting and important finds of this work is influence of genetic variability in the genes of FBLN5 and LOXL1 on the complex of often concomitant diseases with the expressed connecting-tissue component of pelvic organ prolapse.