Clinical­and­endocrinological features of hyperproliferative processes of uterus and mammary glands for the women of reproductive age

Abstract

DOI: 10.52705/2788-6190-2025-02.1-11
УДК 618.19:618.14-007.6:618.17/.5-02:616.43/.45-039

The objective: to estimate clinical-and-endocrinological features of hyperproliferative processes of uterus and mammary glands for the women of reproductive age.
Materials and methods. In research the included women of reproductive age are with the hyperplastic processes of endo – and myometrium and 30 healthy women which did not have pathology of endo – and myometrium (control group). A basic group was made 90 patients which parted on 3 sub-groups: in a 1th sub-group patients are plugged with combination of leiomyoma of uterus and adenomyosis (n = 30); in a 2th sub-group are patients with the leiomyoma of uterus in combination with the hyperplastic processes of endometrium (n = 30); in a 3th sub-group are patients which have combination of leiomyoma of uterus, adenomyosis and hyperplasia of endometrium (n = 30). The group of comparison was made by 90 patients which parted on 3 sub-groups: sub-group A are patients with the isolated leiomyoma of uterus (n = 30); sub-group B – with isolated adenomyosis (n = 30); sub-group C – with the isolated hyperplastic processes of endometrium (n = 30). To the complex of the conducted researches clinical, laboratory instrumental and statistical methods were included.
Results. Among 180 patients with the of high quality hyperplastic processes of uterus fibro-cystic disease of mammary glands was had 59%; diffuse form – 66% and focal – 34% women. In the control group of signs fibro-cystic disease was not found out in any case. Fibro-cystic disease of mammary glands for certain more frequent appeared for patients with the combined hyperplastic processes of uterus – at 78,3 ± 1,9% cases, what for patients with the isolated proliferative processes of uterus – in 42,3 ± 2,1% (р < 0,001).
Statistically appeared reliable (р < 0,05) and higher frequency by a focal form fibro-cystic disease in a basic group, what in the group of comparison. The biopsy of ешіігу of mammary glands performed to 36 patients with a focal form fibro-cystic disease. At histological research of biopsies in 32% cases found out a proliferative form fibro-cystic disease without atypia, in 68% is a non-proliferative form. For the patients of basic group for certain more frequent than in the group of comparison a proliferative form appeared fibro-cystic disease. Relative risk of breast cancer during 5 on the criterion of Geyla for patients 36–45 years from solitary by the hyperplastic processes of uterus for certain higher than for the healthy women of group of control of that age, but below what for patients with the combined hyperplastic processes of endo- and myometrium.
Conclusions. The results of the conducted researches testify that to the factors of risk of development of the combined of high quality proliferative diseases of endo- and myometrium for the women of reproductive age belong presence for the patient of obesity, diseases of the cardiovascular system, alimentary canal and hepatobiliry system. Patients with a proliferative form fibrocystic disease of mammary glands behave the combined hyperplastic diseases of uterus to the group of high risk of development of breast cancer. In pathogeny of the combined forms of high quality hyperplastic diseases of uterus in reproductive
age play a leading role hormonal deficiency of ovarian function, which appears anovulation and insufficiency of luteal phase.