Women have features of function of ovaries with the plural hyperplastic processes of organs of the reproductive system

Abstract

DOI: 10.52705/2788-6190-2025-3-09
УДК 618.17/.5-007.61-02:618.11-039

Research purpose. To estimate the features of function of ovaries for women with the plural hyperplastic processes of organs of the reproductive system.
Materials and methods. For the decision of the put purpose 74 women are inspected. To the basic group entered 54 patients with two and by more hyperplastic processes of organs of the reproductive system (uterine fibroids, hyperplasia and endometrial polyps, adenomyosis, external genital endometriosis, fibro-cystic mastopathia). A control group was made by 20 women from ovulatory menstrual cycle, middle duration of 28,4±0,8 day. Except for clinical and echographic methods, for research to the function of ovaries determined maintenance in blood of estradiol on 5-7 day of menstrual cycle, progesterone on 20-24 days of menstrual cycle.
Results. Depending on character of menstrual cycle, the most high maintenance of estradiol as compared to an analogical index in the group of control was observed for women with anovulation - 298,2±11,7 pmol/l (р<0,05). The level of progesterone in blood of patients of basic group with a valuable ovulatory cycle (43,8±4,6 nmol/l) was comparable with the index of control group (45,1±4,9 nmol/l, р>0,05). At insufficiency of luteal phase of menstrual cycle a level of progesterone was more than in two times below (18,8±1,1 nmol/l) than for women with a ovulatory cycle (43,8±4,6 nmol/l, p< 0,01) and in a control group (45,1±4,9 nmol/l, p< 0,01).
Conclusion. Findings pictures confirm and complement of nosotropic role relative and absolute hyperestrogenemia in development of plural hyperplastic diseases of organs of the reproductive system. Findings must be taken into account at development of algorithm of diagnostic and treatment-and-prophylactic measures for women with the plural hyperplastic processes of endometrium.