Criteria of estimation of significance of differences of results depending on matrimonial pair have actions of risk factors at infertility

Abstract

DOI: 10.52705/2788-6190-2025-3-15
УДК 618.177-068.833-06-036.8

Research purpose. To set the criteria of estimation of significance of differences of results depending on the action of risk factor at infertility at matrimonial pair and application of donor oocytes.
Materials and methods. In obedience to the put purpose 135 women were up-diffused on three clinical groups. In a basic group women were plugged with making progress pregnancy after the oocyte donation (n=32). In a group comparisons are women with making progress pregnancy after in vitro fertilization without the donor programs (n=53). A control (n=50) group was formed with including de bene esse of healthy women with spontaneously coming pregnancy in the natural menstrual loop, with the physiological course of pregnancy and births. Plugging criteria in a basic group: reproductive age, desirable pregnancy, application of oocyte donation because of reductions ovarian reserve. Plugging criteria in the group of comparison: reproductive age, desirable pregnancy, application of assisted reproductive technologies without the oocyte donation. Criteria of exception for all groups: surrogacy, other testimonies for the oocyte donation, except for reductions ovarian reserve, obstetric or extragenital pathology with the high risk of decompensation. Clinical, laboratory, instrumental and statistical methods were plugged in the complex of the conducted researches.
Results.It turned out at the analysis of reproductive anamnesis, that only in 6% women of the II group there were involuntary abortions in anamnesis. Women from oocyte donation, more credible than all, did not have abortions in anamnesis through considerable violations of reproductive function, that appeared reason of primary infertility in 72% women. Reliable difference in an amount the attempts in vitro fertilization discovered it was not. That for women which requested the oocyte donation, frequency of unsuccessful attempts in vitro fertilization did not excel such as compared to women without the oocyte donation. A maximal number of attempts in vitro fertilization women with the oocyte donation had 7, Me=2, and for women with in vitro fertilization without the oocyte donation maximal number of attempts in vitro fertilization– 6, Me=1. However, a mean value appeared comparable for the women of both groups: 2,74±0,3 vs. 2,23±0,27, р>0,05. Without regard to that for women from oocyte donation for certain more frequent found out in anamnesis factors which influence mainly on the endocrine adjusting of reproductive function, at the analysis of predictable reasons of infertility, which requested assisted reproductive technologies, reliable difference it was not discovered also (р>0,05). For women with in vitro fertilization, independent of necessity of oocyte donation, frequency of exposure tuboperitoneal, endocrine or mixed factor of infertility were comparison.
Conclusion. It is impossible simply to provide for, which motion of pregnancy will be, if it was planned, desired, such, which came on a background the reception of female sex hormones, improvement of the states of rheology and aggregate to blood, prophylaxises of deficit of folic acid and hyperhomocysteinimia (I-II of group), or that came spontaneously, it is not planned, in 82% women de bene esse healthy, but off preconception preparation. The got results must be taken into account at development of algorithm of diagnostic and treatment-and-prophylactic measures.