Women have features of quality of life with the different forms of osteoporosis

Abstract

DOI: 10.52705/2788-6190-2026-01-11
УДК 616.71-007.234-055.2-039:303.022:314.47

The objective: to estimate quality of life for women with the different forms of osteoporosis.
Materials and methods. Monitoring of indexes of quality of life was conducted for 162 women with natural postmenopause and surgical postmenopause, three groups were formed: I (basic) group which consists of 35 women from osteopenia and by an osteoporosis, that got a hormone replacement therapy during 12 months. From them 10 (28,6 %) patients were in the period of natural postmenopause and last 25 (71,4 %) – in surgical postmenopause. 27 women got the continuous combined hormone replacement therapy; 3 patients – continuous monotherapy by estrogen; a tissue selective modulator of estrogen receptors is 5 women. During the first three months from treatment renounced 5 patients. The II (control) group is formed from 63 patients from osteopenia and by an osteoporosis, that got a diet, rich in a calcium (1200-1500 milligrams of calcium are on days). From them 25 (39,7 %) women were in natural postmenopause and 38 (60,3 %) – in surgical postmenopause. The III group (comparison) is presented by 64 women in the period of surgical postmenopause without osteopenia and to the osteoporosis.
Results. At the comparative analysis of data of the special questionnaire OPAQ on the points of research (T) by the method of analysis of variance in I found out a group the improvement of parameters 10 from 17 scales of questionnaire: from T2 of supervision is mobility, changing between standing and sitting positions, fear of falling, pain, sleep, fatigue, level of tension, original appearance, independence and from T3 is a mood. At comparing in pairs of four points to application of the special amendment for multiple comparisons on all scales, except for mobility and changing between standing and sitting positions, the increase of indexes of quality of life is confirmed. The scale of work (employment) was not analysed because of small number of workings women. Also positively parameters changed 2 from 4 analysable domens: symptoms are with T2 of therapy and physical activity from T3. Indexes only of 3 scales of OPAQ became better in the II group: social activity, independence and level of tension, is last at the special amendment from T3 of supervision. A domen is physical activity became better in 12 months of research. At comparison of indexes of quality of life of I and II groups found out reliable differences for 14 from 17 scales and to four domens in behalf of patients which accepted a hormone replacement therapy. The scales of I of group are listed walking and bending, retraining (time to get up and sit down), support from the side of family and friends and social activity was above complemented by scales, thus changes in the last were related to the improvement of this aspect of quality of life in the II group. Statistically the meaningful differences of scales and domens of two groups were observed from T2 of research, except for a scale mood and domen psychological status – from T3. Indexes of scales of dressing and reaching for the objects, self-service and implementation of work on a house did not differ in groups, that is related to their practically normal values in T1 and with absence of inability of patients to self-service.
Conclusions. The presented analysis of data led to the improvement of all constituents of quality of life of patients, sufferings the osteoporosis of postmenopause convincingly, under act of etiotropic hormone replacement therapy. On a background a hormone replacement therapy there is a substantial, early and stable improvement of indexes of quality of life of patients of osteopenia and by an osteoporosis on all scales of general questionnaires of SF-36 and EQ-5D, on most and all basic domens of the special questionnaire OPAQ scales as compared to women, which got a diet, rich in a calcium. The got results must be taken into account at development of algorithm of treatment-andprophylactic measures.