Tactics for predicting hyperproliferative processes of the uterus in women of reproductive age

Abstract

DOI: 10.52705/2788-6190-2026-02-7
УДК 618.14-006.03-02:618.17/.5-037

The objective: to develop tactics for predicting hyperproliferative processes of the uterus in women of reproductive age.
Materials and methods. The study included 1002 women of reproductive age with hyperplastic processes of the endo- and myometrium and 80 healthy women who did not have pathology of the endo- and myometrium (control group). The main group consisted of 470 patients, who were divided into 3 subgroups: the 1st subgroup included patients with a combination of uterine leiomyoma and adenomyosis (n = 109); the 2nd subgroup – patients with uterine leiomyoma combined with endometrial hyperplastic processes (n = 179); the 3rd subgroup – patients having a combination of uterine leiomyoma, adenomyosis, and endometrial hyperplasia (n = 182). The comparison group consisted of 532 patients, who were divided into 3 subgroups: subgroup A – patients with isolated uterine leiomyoma (n = 147); subgroup B – with isolated adenomyosis (n = 143); subgroup C – with isolated endometrial hyperplastic processes (n = 242).
Results. The risk of leiomyoma occurrence in a patient with the presence of endocrine system diseases can be assessed using the following function: Risk of leiomyoma development: 1.979 • variable value for obesity + 0.102 • variable value for autoimmune thyroiditis + 0.064 • variable value for diabetes mellitus + 0.046 • age – 2.445. Variable values for diabetes mellitus, autoimmune thyroiditis, obesity: 0 – absence of the disease, 1 – presence. If the function value is closer to zero, the risk of developing uterine leiomyoma is minimal; if closer to 1, the risk is high.
Conclusions. Risk factors for the development of combined benign proliferative diseases of the endo- and myometrium in women of reproductive age include the presence of obesity, diseases of the cardiovascular system, gastrointestinal tract, and hepatobiliary system in the patient. Features of the clinical course of combined uterine hyperplastic processes, unlike solitary ones, are: a significantly higher frequency and intensity of pain syndrome, the prevalence of various forms of uterine bleeding and anemia caused by them, including severe degrees. Patients with the proliferative form of fibrocystic breast disease and combined hyperplastic diseases of the uterus belong to the high-risk group for developing breast cancer.