Features of pathogenesis of the intrauterine infection

Abstract

DOI: 10.52705/2788-6190-2025-3-04
УДК 618.33-022.7-053.1-092-039

Research purpose. To learn the features of pathogenesis of the intrauterine infection.
Materials and methods. For the decision of the put purpose the followings groups of patients were formed: in a 1 group entered 111 pregnant with the presence of antibodies of class of G to Chlamydia of trachomatis in a title 1:5-1:40, without the clinical displays of disease in mothers, with the signs of the intrauterine infection from the term of pregnancy 18-20 weeks, without antibacterial therapy during pregnancy, inspected in a term 13-24 weeks and in 38-40 weeks of gestation. 2 groups were presented 45 pregnant with the presence of high-avidity antibodies of class of G to Herpes of simplex 1,2 without the clinical displays of which or disease in mothers, with the signs of the intrauterine infection from the term of pregnancy 18-20 weeks (polyhydramnios, fetal growth retardation, thickening of placenta, suspension in amniotic fluid and ets), without medicinal therapy during pregnancy, inspected in a term 38-40 weeks gestation. 3 groups were made 45 pregnant with the presence of Candida of albicans 104-106 CFU/l, without the clinical displays of infectious disease in mothers, with the signs of the intrauterine infection from the term of pregnancy of 18- 20 weeks (polyhydramnios, fetal growth retardation, thickening of placenta, suspension in amniotic fluid and ets), without medicinal therapy during pregnancy, inspected in a term 38-40 weeks gestation. Delivery through natural birth canal in the term of gestation 38-40 weeks. 4 groups consisted of 43 pregnant from Staphylococcus of aureus, without the clinical displays of infectious disease in mothers, with the signs of the intrauterine infection from the term of pregnancy 18-20 weeks (polyhydramnios, fetal growth retardation, thickening of placenta, suspension in amniotic fluid and ets), without medicinal therapy during pregnancy, inspected in a term 38-40 weeks gestation. Delivery through natural birth canal in the term of gestation 38-40 weeks. A to 5 group entered 157 pregnant transmitters of exciters of mixt-infection, without the clinical displays of infectious disease during all pregnancy, with the signs of the intrauterine infection from the term of pregnancy 18-20 weeks (polyhydramnios, fetal growth retardation, thickening of placenta, suspension in amniotic fluid and ets), without antibacterial therapy during pregnancy, inspected in a term 38-40 weeks gestation. Delivery through natural birth canal in the term of gestation 38-40 weeks.
To the complex of the conducted researches were included clinical, echographic, laboratory, microbiological and statistical methods. From laboratory indexes the special attention was spared to determination content alpha-2-macroglobulin, to the lactoferrin and albumen in blood and amniotic fluid.
Results. For all puerperas with the transmitter of exciters perinatal meaningful infections in mixtures and birth of children with a intrauterine infection found out the meaningful decline of indexes of albumen in the whey of blood as compared to control which testifies to the presence of inflammatory processes. Table of contents of albumen in amniotic fluid of puerperas with the mixtures transmitter of exciters perinatal meaningful infections was analogical to content at mono-carriage of the studied exciters of infections in sub-groups, where necessarily there were antibodies to Her. Simplex, and also St. Aureus or Can.albicans, however, if at mono-carriage of IgG of antibodies to Chlamydia of trachomatis increase of level of albumen was frequent, then at mixtures of contagiums these changes absented actually. At an analysis each of variants of mixtures found out that the most considerable changes were observed at mixtures of Candida of albicans with the transmitter of IgG Herpes simplex 1,2 or Chlamydia of trachomatis. Like and at the analysis of the mixed groups the most considerable changes are fixed in the case when in composition mixtures necessarily there was Candida of albicans. On the whole, levels of albumen in amniotic fluid at the transmitter of mixtures of exciters perinatal meaningful infections were enhanceable at the transmitter of all exciters, except for Staphylococcus of aureus.
Conclusion. The transmitter of exciters in mixtures amends in pathogenesis of processes which take place at mono-carriage exciters of infections. Especially notedly it at comparison of mono-mixtures-carriage of Chlamydia of trachomatis. However on the whole, changes of indexes of immunoregulatory albumens for pregnant and puerperas at the risk of birth of children with the intrauterine infection at a mixtures transmitter analogical such at mono-carriage, that is why can be used in clinical practice for the prognosis of the intrauterine infection, complicated by the infectious process of motion of early neonatal period in new-born.