Comparative aspects of the functional state of the system are a mother­placenta­fetus at the antenatal fetal hypoxia

Abstract

DOI: 10.52705/2788-6190-2025-3-06
УДК 618.33-001.8:618.3/.36-008-07

Research purpose. To estimate the comparative aspects of the functional state of the system mother-placenta-fetus at a antenatal hypoxia.
Materials and methods. A basic (1th) group was made by 55 cases of death of fetus from a antenatal hypoxia in terms of 23-40 weeks at a singleton pregnancy: 55 placentas and 52 fetuses (in 3 cases a section was not produced). These 55 the most difficult for diagnostics supervisions of antenatal fetal death were included by us in a 1 group of research on the basis of the unspecified nosotropic role of placenta and not clear tanatofenesis, they were 52% all antenatal losses. Cases of antenatal death of the set etiology - with infectious fetopathy, by innate teratosiss, incompatible with a antenatal period, - from research eliminated, as well as multiple pregnancy. Three groups of comparing to birth living new-born, without regard to threatenings lives of fetus will become a draught pregnancies, formed on the basis of clinical estimation of weight of placenta dysfunction and result of pregnancy, – all investigational 46 placentas of new-born in terms of 25-40 weeks at a singleton pregnancy. To the complex of the conducted researches were included clinical, echographic, doppler, cardiotocographic and statistical.
Results. Placenta dysfunction is compensated with the worn pregnancy and favourable perinatal result characterized by the low levels of placenta lactogen (Me=5,8 P) and estriol (Me=0,7 P) at mean values levels of progesterone, alpha-fetoprotein and cortisol, by the low biometrical fetal parameters – biparietal diameter of head (Me=10 P), diameter thorax (Me=15 P) and abdomen (Me=10 P) at the mean values of length of femur (Me=54,25 P) and thickness of placenta (Me=71,3 P), by most frequency of fetal growth retardation II-III of degree and oligohydramnios. The pregnant of this group are younger (Me=24 years) in all, without predominance of severe preeclampsia in a nosology spectrum.
Conclusion. A comparative estimation is conducted clinical-and-functional features of the system mother-placenta-fetus at a antenatal hypoxia from without and with fetal losses. The got results must be taken into account at development of algorithm of diagnostic and treatment-and-prophylactic measures.