Conformities to law of forming compensatory­adaptive reactions of the psychoemotional state and difference in the mechanisms of their realization at the different forms of diffuse dishormonal dysplasia of mammary glands

Abstract

DOI: 10.52705/2788-6190-2025-3-12
УДК 618.19-007.17:612.621.31]-003.96-036:159.922.27

Research purpose. To estimate conformities to law of forming compensatory-adaptive reactions of the psychoemotional state and difference in the mechanisms of their realization at the different forms of diffuse dishormonal dysplasia of mammary glands.
Materials and methods. Research material information, got at an inspection 120 patients with diffuse dishormonal dysplasia of mammary glands, served as. Appeared the criteria of including presence of diffuse dishormonal dysplasia of mammary glands; absence of nodular forms of dishormonal dysplasia of mammary glands; age from 18 to 45 years; a reproductive function is preserved; the informed consent is to participate in research. A control group included 30 somatically healthy women, comparable with a basic group on age. On the first stage of research patients were up-diffused on 4 clinical groups with diffuse dishormonal dysplasia of mammary glands with predominance of glandular (I group), cystic (II group), fibrotic (III group) component and mixed form (IV group). Diffuse dishormonal dysplasia of mammary glands in accordance with modern criteria was diagnosed on the basis of complaints, information of anamnesis, estimation of general and gynaecological statuses, ultrasonic scan-out of mammary glands. To the complex of methods of researches clinical, laboratory instrumental and statistical methods were included.
Results. It is set that diffuse dishormonal dysplasia of mammary glands forms the different from the state of health structure of cross-correlation matrix – structure of the homoeostatic adjusting with participation of all analysable parameters. Thus to every form of mastopathy peculiar certain features of their intercommunications. In providing of homoeostasis for glandular, cystic and mixed forms indisputable is priority of regulator influences of the vegetative nervous system. Here «enriching» of connections of the system of the vegetative providing of functions and realizing for stress hormones comes forward an of principle difference meaningfulness at a cystic form and practically even number of connections which are on a heterospecific and specific hormonal type at glandular and mixed forms. The function of system-organizing structure in a group with a fibrotic form passes to the contour of realizing for stress and specific hormones. Some differences of expressed of parameters of thyroid hormonal status are marked in providing of the proper level of homoeostasis in groups from diffuse dishormonal dysplasia of mammary glands. It is known that a hypothyroidism which is accompanied by the increase of level of thyrotropic hormone is instrumental in the increase of content of prolactin, due to strengthening of secretion of thyroliberin. Pathology of thyroid causes the change of functioning of vegetative nervous system, here, more frequent there is strengthening of activity of a stress, likable department. The most expressed (as compared to control) participating of this homeostat in support of optimum of vital functions is determined for patients with the glandular and mixed form of mastopathy, less expressed – with a fibrotic and cystic form. However, the basic difference of structural organization of the systems of life-support in a number of different clinical-and-morphological forms of mastopathy is «tension» in the investigational systems, that increases, it appears in growth of number of meaningful connections between the separate constituents of homoeostasis.
Conclusion. It is set that consider the changes of specific hormonal activity the basic nosotropic link of origin and progress of mastopathy. Therefore priority direction in treatment of diffuse dishormonal dysplasia of mammary glands is a hormonotherapy the conduct of which does not change the condition of support of homoeostasis, that formed. In same queue, the correction of vegetative violations can be carried out by facilities which own adaptogenic properties.