Features of endocrinological and immunological status at gynaecological morbidity for women with connective tissue dysplasia

Abstract

DOI: 10.52705/2788-6190-2025-3-10
УДК 618.1-018-007.17:616.43/.45-07:612.017]-039

Research purpose. To learn the features of endocrinological and immunological status at gynaecological morbidity for women with connective tissue dysplasia.
Materials and methods. To implement our goals by us an inspection and treatment was conducted 688 patients reproductive, pre- and postmenopausal periods. In accordance with a purpose and research tasks four groups of patients were plugged in the real work, in each of which selected a group with connective tissue dysplasia and without it. Clinical, laboratory, instrumental and statistical methods were plugged in the complex of the conducted researches.
Results. At the comparative analysis of indexes of immune status for patients with connective tissue dysplasia and without it, it is possible to draw conclusion, that the results of IgG and IgA in both groups do not differ practically. Women have levels of IgМ a bit higher with connective tissue dysplasia. The most meaningful differences are at comparison of results of IgЕ, circulatory immune complexes, C3- and C4-component of complement. Amount of IgE for the patients of reproductive period with pathology of connecting fabric almost at 1,5 time more than for patients without connective tissue dysplasia. For the women of pre- and postmenopausal periods with connective tissue dysplasia fabric except for the reliable increase of level of IgЕ the increase of amount of circulatory immune complexes is marked at 1,8 time, decline of C3- C4-component to complement respectively in 1,8 and 1,5 times.
Conclusion. At insignificant changes in the indexes of immune status there is not a necessity for setting of immunomodulatory therapy. And only at considerable changes and in the case of worsening of indexes of immune status during a dynamic supervision it is necessary to decide a question about setting of immune preparations. Findings must be taken into account at development of algorithm of treatment-and-prophylactic measures.